Phase diagram for K(1-x)(NH4)(x)H2PO4 (x = 0 – 0.15) solid solutions embedded into magnetic glasses

Effect of magnetic field application on phase transition in nanostructured solid solutions (1-x)KH2PO4 – (x)(NH4)H2PO4 at x = 0, 0.05 and 0.15 has been studied by dielectric spectroscopy at B = 0 – 10T. The samples have been prepared by impregnation of magnetic porous glasses by KDP-ADP solid solutions. The average pore diameter in glasses was 50(5) nm. The temperatures of the ferroelectric phase transition have been determined, and the phase diagrams for these nanocomposite materials (NCM) on cooling and heating (including at magnetic field application) were constructed. The interface “matrix-nanoparticles” was shown to play the principal role in phase diagram formation

КОНЦЕПТ В ЛИНГВОДИДАКТИЧЕСКОЙ ПРАКТИКЕ ПРЕПОДАВАТЕЛЯ ИНОСТРАННОГО ЯЗЫКА ДЛЯ СПЕЦИАЛЬНЫХ ЦЕЛЕЙ (LSP)

The article focuses on linguocognitive characteristics of the concept that are relevant to teach LSP. Functional repertories of the concept are evaluated from the Didactics angle. The core of correlation between the concept, notion, and meaning is revealed. The Competence Approach is used to ground an urgent need to develop and train skills of interpreting specialized professional knowledge concepts.В статье рассматриваются лингвокогнитивные характеристики концепта, релевантные для методики преподавания иностранного языка как языка специальности, в дидактическом аспекте обсуждается вопрос о соотношении концепта, понятия и значения, необходимость формирования навыков интерпретации специальных концептов обосновывается с позиций компетентностного подхода

Detecting best lag of embedding for modeling spike-wave discharges from experimental data

Item does not contain fulltextPurpose. Optimal value of the embedding lag calculation is made. Lag is one of empirical parameters of mathematical models, used in autoregressive models for prediction, coupling analysis, signal classification etc. Methods. The first minimum in the dependence of the mutual information function on the time lag was detected. Results. The calculation showed that the optimal lag is about 8 sampling intervals (1/64 s or 1/8 of the characteristic oscillation period for the absence seizures). Discussion. The optimal lag is about 1/8 of the characteristic oscillation period was obtained for both epileptiform and background activity, including preictal and different stages of ictal activity, i. e. this time scale is present in the signal throughout the observation time.The 23nd Annual Conference Saratov Fall Meeting 2019 VII Symposium on Optics & Biophotonics (Saratov, Russia, September 23-27, 2019

Connectivity detection in application to spike-wave discharge study

Contains fulltext : 227417.pdf (publisher's version ) (Open Access)In our study, we compare three popular approaches to directed coupling analysis, in particular transfer entropy and two types of Granger causality, applied to real data from genetic absence epilepsy rats. We have chosen the channels for which the coupling architecture is already well known from previous studies. Recordings from 5 WAG/Rij rats of 8 hours duration with at least 28 spontaneous seizures of length not less than 6 s in each recording were studied. To test results for significance, surrogate signals based on series permutation technique were constructed. Connectivity development in time was investigated by considering six two-second intervals before, during and after the seizure. Our outcomes showed large differences between studied approaches, while all of them exploit the same general idea. Transfer entropy demonstrated the smallest number of significant couplings throughout all three considered measures, while the linear Granger causality showed the largest number of them. This indicates that transfer entropy is the most conservative measure and the least sensitive one. Its sensitivity is affected by insufficient series length. The linear Granger causality is likely to demonstrate insufficient specificity.12 p

Therapeutic potential of human mesenchymal stromal cells secreted components: A problem with standartization

Regenerative medicine approaches, such as replacement of damaged tissue by ex vivo manufactured constructions or stimulation of endogenous reparative and regenerative processes to treat different diseases, are actively developing. One of the major tools for regenerative medicine are stem and progenitor cells, including multipotent mesenchymal stem/stromal cells (MSC). Because the paracrine action of bioactive factors secreted by MSC is considered as a main mechanism underlying MSC regenerative effects, application of MSC extracellular secreted products could be a promising approach to stimulate tissue regeneration; it also has some advantages compared to the injection of the cells themselves. However, because of the complexity of composition and multiplicity of mechanisms of action distinguished the medicinal products based on bioactive factors secreted by human MSC from the most of pharmaceuticals, it is important to develop the approaches to their standardization and quality control. In the current study, based on the literature data and guidelines as well as on our own experimental results, we provided rationalization for nomenclature and methods of quality control for the complex of extracellular products secreted by human adipose-derived MSC on key indicators, such as "Identification", "Specific activity" and "Biological safety". Developed approaches were tested on the samples of conditioned media contained products secreted by MSC isolated from subcutaneous adipose tissue of 30 donors. This strategy for the standardization of innovative medicinal products and biomaterials based on the bioactive extracellular factors secreted by human MSC could be applicable for a wide range of bioactive complex products, produced using the different types of stem and progenitor cells

Network analysis reveals a role of the hippocampus in absence seizures: The effects of a cannabinoid agonist

The role of the hippocampus (Hp) in absence epileptic networks and the effect of endocannabinoid system on this network remain enigmatic. Here, using adapted nonlinear Granger causality, we compared the differences in network strength in four intervals (baseline or interictal, preictal, ictal and postictal) in two hours before (Epoch 1) and six hours (epochs 2, 3 and 4) after the administration of three different doses of the endocannabinoid agonist WIN55,212–2 (WIN) or solvent. Local field potentials were recorded for eight hours in 23 WAG/Rij rats in the Frontal (FC), Parietal PC), Occipital Cortex (OC) and in the hippocampus (Hp). The four intervals were visually marked by an expert neurophysiologist and the strength of couplings between electrode pairs were calculated in both directions. Ictally, a strong decrease in coupling strength was found between Hp and FC, as well as a large increase bidirectionally between PC and FC and unidirectionally from FC and PC to OC, and from FC to Hp over all epochs. The highest dose of WIN increased the couplings strength from FC to Hp and from OC to PC during 4 and 2 hr respectively in all intervals, and decreased the FC to PC coupling strength postictally in epoch 2. A single rat showed generalized convulsive seizures after the highest dose: this rat shared not only coupling changes with the other rats in the same condition, but showed many more. WIN reduced SWD number in epoch 2 and 3, their mean duration increased in epochs 3 and 4. Conclusions:during SWDs FC and PC are strongly coupled and drive OC, while at the same time the influence of Hp to FC is diminished. The first is in agreement with the cortical focus theory, the latter demonstrates an involvement of the hippocampus in SWD occurrence and that ictally the hippocampal control of the cortico-thalamo-cortical system is lost. WIN causes dramatic network changes which have major consequences for the decrease of SWDs, the occurrence of convulsive seizures, and the normal cortico-cortical and cortico-hippocampal interactions

Therapeutic potential of human mesenchymal stromal cells secreted components: A problem with standartization

Regenerative medicine approaches, such as replacement of damaged tissue by ex vivo manufactured constructions or stimulation of endogenous reparative and regenerative processes to treat different diseases, are actively developing. One of the major tools for regenerative medicine are stem and progenitor cells, including multipotent mesenchymal stem/stromal cells (MSC). Because the paracrine action of bioactive factors secreted by MSC is considered as a main mechanism underlying MSC regenerative effects, application of MSC extracellular secreted products could be a promising approach to stimulate tissue regeneration; it also has some advantages compared to the injection of the cells themselves. However, because of the complexity of composition and multiplicity of mechanisms of action distinguished the medicinal products based on bioactive factors secreted by human MSC from the most of pharmaceuticals, it is important to develop the approaches to their standardization and quality control. In the current study, based on the literature data and guidelines as well as on our own experimental results, we provided rationalization for nomenclature and methods of quality control for the complex of extracellular products secreted by human adipose-derived MSC on key indicators, such as "Identification", "Specific activity" and "Biological safety". Developed approaches were tested on the samples of conditioned media contained products secreted by MSC isolated from subcutaneous adipose tissue of 30 donors. This strategy for the standardization of innovative medicinal products and biomaterials based on the bioactive extracellular factors secreted by human MSC could be applicable for a wide range of bioactive complex products, produced using the different types of stem and progenitor cells